Intrinsic GABAergic system of adrenal chromaffin cells.
نویسندگان
چکیده
منابع مشابه
Kinetics of exocytosis in adrenal chromaffin cells.
Upon repetitive or maintained stimulation, chromaffin cells secrete catecholamines initially at a very high rate which then relaxes with multiple kinetic components. The complex kinetics are often modeled as resulting from the successive depletion of several functional pools of secretory granules which may reflect specific protein-mediated steps in granule maturation. The fastest component repr...
متن کاملPituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin cells.
The discovery that the hypothalamic-pituitary-adrenocortical (HPA) endocrine stress axis controls an alternative splicing decision in chromaffin Slo-encoded BK (big potassium) channels raised the possibility that activation of the HPA could serve as a mechanism to tune the intrinsic electrical properties of epinephrine-secreting adrenal chromaffin cells. To test this, we compared BK functional ...
متن کاملAdrenal medulla: chromaffin cells as paraneurons.
Adrenal chromaffin cells are typical paraneurons. They are of neural crest origin, secrete catecholamines and produce action potentials. In addition to adrenaline-storing (A) cells and noradrenaline-storing (NA) cells, a third calss of chromaffin cells is distinguishable. They are characterized by the smallness of the secretory granules, and hence are called small-granule chromaffin (SGC) cells...
متن کاملVesicle Pools: Lessons from Adrenal Chromaffin Cells
The adrenal chromaffin cell serves as a model system to study fast Ca2+-dependent exocytosis. Membrane capacitance measurements in combination with Ca2+ uncaging offers a temporal resolution in the millisecond range and reveals that catecholamine release occurs in three distinct phases. Release of a readily releasable (RRP) and a slowly releasable (SRP) pool are followed by sustained release, d...
متن کاملMechanism of calcium efflux from isolated bovine adrenal chromaffin cells.
Chromaffin cells isolated from bovine adrenals and maintained in culture were loaded with 45Ca, and the mechanism of 45Ca efflux from these cells was investigated. During exposure to a Ca-deficient, Mg (1 mM)-containing medium, replacement of NaCl with sucrose, choline Cl, or Tris Cl reduced the rate of 45Ca efflux by approx. 30-40%, showing the presence of a Na-dependent 45Ca efflux mechanism....
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1984
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.81.10.3218